LymphedemaV1, Main, Exploration, bibRecord, 002810

Molecular epidemiology, phylogeny and evolution of the filarial nematode Wuchereria bancrofti

Identifieur interne : 002810 ( Main/Exploration ); précédent : 002809; suivant : 002811

Molecular epidemiology, phylogeny and evolution of the filarial nematode Wuchereria bancrofti

Auteurs : Scott T. Small [États-Unis] ; Daniel J. Tisch [États-Unis] ; Peter A. Zimmerman [États-Unis]

Source :

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases [ 1567-1348 ] ; 2014.

RBID : PMC:4257870

Descripteurs français

KwdFr :
- Animaux, Filariose lymphatique (diagnostic), Filariose lymphatique (parasitologie), Filariose lymphatique (transmission), Filariose lymphatique (épidémiologie), Humains, Phylogénie, Prévalence, Typage moléculaire, Variation génétique, Wuchereria bancrofti (), Wuchereria bancrofti (génétique), Épidémiologie moléculaire, Évolution moléculaire.
MESH :
- diagnostic : Filariose lymphatique.
- génétique : Wuchereria bancrofti.
- parasitologie : Filariose lymphatique.
- épidémiologie : Filariose lymphatique.
- Animaux, Humains, Phylogénie, Prévalence, Typage moléculaire, Variation génétique, Wuchereria bancrofti, Épidémiologie moléculaire, Évolution moléculaire.

English descriptors

KwdEn :
- Animals, Elephantiasis, Filarial (diagnosis), Elephantiasis, Filarial (epidemiology), Elephantiasis, Filarial (parasitology), Elephantiasis, Filarial (transmission), Evolution, Molecular, Genetic Variation, Humans, Molecular Epidemiology, Molecular Typing, Phylogeny, Prevalence, Wuchereria bancrofti (classification), Wuchereria bancrofti (genetics).
MESH :
- classification : Wuchereria bancrofti.
- diagnosis : Elephantiasis, Filarial.
- epidemiology : Elephantiasis, Filarial.
- genetics : Wuchereria bancrofti.
- parasitology : Elephantiasis, Filarial.
- transmission : Elephantiasis, Filarial.
- Animals, Evolution, Molecular, Genetic Variation, Humans, Molecular Epidemiology, Molecular Typing, Phylogeny, Prevalence.

Abstract

Wuchereria bancrofti (Wb) is the most widely distributed of the three nematodes known to cause lymphatic filariasis (LF), the other two being Brugia malayi and B. timori. Current tools available to monitor LF are limited to diagnostic tests targeting DNA repeats, filarial antigens, and anti-filarial antibodies. While these tools are useful for detection and surveillance, elimination programs have yet to take full advantage of molecular typing for inferring infection history, strain fingerprinting, and evolution. To date, molecular typing approaches have included whole mitochondrial genomes, genotyping, targeted sequencing, and random amplified polymorphic DNA (RAPDs). These studies have revealed much about Wb biology. For example, in one study in Papua New Guinea researchers identified 5 major strains that were widespread and many minor strains some of which exhibit geographic stratification. Genome data, while rare, has been utilized to reconstruct evolutionary relationships among taxa of the Onchocercidae (the clade of filarial nematodes) and identify gene synteny. Their phylogeny reveals that speciation from the common ancestor of both B. malayi and Wb occurred around 5–6 millions years ago with shared ancestry to other filarial nematodes as recent as 15 million years ago. These discoveries hold promise for gene discovery and identifying drug targets in species that are more amenable to in vivo experiments. Continued technological developments in whole genome sequencing and data analysis will likely replace many other forms of molecular typing, multiplying the amount of data available on population structure, genetic diversity, and phylogenetics. Once widely available, the addition of population genetic data from genomic studies should hasten the elimination of LF parasites like Wb.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4257870

DOI: 10.1016/j.meegid.2014.08.018
PubMed: 25176600
PubMed Central: 4257870

Affiliations:

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<front><div type="abstract" xml:lang="en"><p id="P2"><italic>Wuchereria bancrofti</italic>
 (Wb) is the most widely distributed of the three nematodes known to cause lymphatic filariasis (LF), the other two being <italic>Brugia malayi</italic>
 and <italic>B. timori</italic>
. Current tools available to monitor LF are limited to diagnostic tests targeting DNA repeats, filarial antigens, and anti-filarial antibodies. While these tools are useful for detection and surveillance, elimination programs have yet to take full advantage of molecular typing for inferring infection history, strain fingerprinting, and evolution. To date, molecular typing approaches have included whole mitochondrial genomes, genotyping, targeted sequencing, and random amplified polymorphic DNA (RAPDs). These studies have revealed much about Wb biology. For example, in one study in Papua New Guinea researchers identified 5 major strains that were widespread and many minor strains some of which exhibit geographic stratification. Genome data, while rare, has been utilized to reconstruct evolutionary relationships among taxa of the <italic>Onchocercidae</italic>
 (the clade of filarial nematodes) and identify gene synteny. Their phylogeny reveals that speciation from the common ancestor of both <italic>B. malayi</italic>
 and Wb occurred around 5–6 millions years ago with shared ancestry to other filarial nematodes as recent as 15 million years ago. These discoveries hold promise for gene discovery and identifying drug targets in species that are more amenable to in vivo experiments. Continued technological developments in whole genome sequencing and data analysis will likely replace many other forms of molecular typing, multiplying the amount of data available on population structure, genetic diversity, and phylogenetics. Once widely available, the addition of population genetic data from genomic studies should hasten the elimination of LF parasites like Wb.</p>
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Serveur d'exploration sur le lymphœdème

Molecular epidemiology, phylogeny and evolution of the filarial nematode Wuchereria bancrofti

Molecular epidemiology, phylogeny and evolution of the filarial nematode Wuchereria bancrofti

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

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	Serveur d'exploration sur le lymphœdème
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